Metabolomics Biomarkers of Neurodegeneration

Client

Corewell Health is a not-for-profit health system that provides health care and coverage with an exceptional team of 65,000+ dedicated people, including more than 12,000 physicians and advanced practice providers and more than 15,500 nurses providing care and services in 21 hospitals, 300+ outpatient locations and several post-acute facilities, and Priority Health, a provider-sponsored health plan serving more than 1.3 million members.

Background

Identify small molecules that could be used for diagnostics of various neurological conditions and neurodegenerative disorders.

Solutions

  • Targeted and untargeted mass spectrometry data processing pipeline
  • Integration of metabolomics, epigenomics and other data sources
  • AI-based predictors for diagnostics and identification of novel therapeutic targets

Publications

Scientific Reports, read full article: Link
Genes, read full article: Link

Cover image credits: Anusorn / Adobe Stock

Similar Resources

Success stories
November 25, 2025

How VUGENE Analysis Shed Light on the Inflammatory Impacts of Phenolic-Containing Insulin Preservatives in Commercial Insulin Formulations

Client Dr. Ulrike Menkes, Wayne State University Background Insulin phenolic preservatives (IPPs) are added to all commercial insulin formulations to ensure insulin stability, extend shelf life, and provide bactericidal properties. ...

Hand holding Zika test with blood
Success stories
June 12, 2024

Detection of Differentially Methylated Regions Using Persimmon and Its Application to Study Epigenetic Changes in Zika Virus Infection

Background Zika virus is a mosquito-borne disease and its infection has no or mild symptoms in the majority of cases. However, Zika virus infection during pregnancy is associated with severe ...