VUGENE highlights a study on the rejuvenation of epigenetic age in multiple rat organs through the use of young porcine plasma fraction. Researchers investigated how plasma derived from young pigs could significantly reduce the epigenetic age across various rat tissues, including the heart, liver, blood, and hypothalamus, utilizing six different epigenetic clocks designed specifically for rats.
Key insights from the study:
Epigenetic reversal
Young porcine plasma treatment significantly reversed epigenetic aging, reducing the biological age by more than half, as measured by multiple epigenetic clocks across various tissues.
Improved organ function
The treatment led to notable improvements in organ function and cognitive performance in aging rats.
Immune system shift
The plasma fraction shifted immune system markers from pro-inflammatory to anti-inflammatory state.
These findings highlight exciting possibilities for rejuvenating aged tissues and open new avenues for therapeutic strategies to combat aging and age-related diseases. The study suggests that transferring plasma between species, specifically from pigs to rats, can rejuvenate certain tissues, offering insights into shared biological mechanisms relevant to human health.
VUGENE team is proud and happy to have contributed to this article.
Steve Horvath, Kavita Singh, Ken Raj, Shraddha I. Khairnar, Akshay Sanghavi, Agnivesh Shrivastava, Joseph A. Zoller, Caesar Z. Li, Claudia B. Herenu, Martina Canatelli-Mallat, Marianne Lehmann, Siniša Habazin, Mislav Novokmet, Frano Vučković, Leah C. Solberg Woods, Angel Garcia Martinez, Tengfei Wang, Priscila Chiavellini, Andrew J. Levine, Hao Chen, Robert T. Brooke, Juozas Gordevicius, Gordan Lauc, Rodolfo G. Goya & Harold L. Katcher. (2024). Reversal of biological age in multiple rat organs by young porcine plasma fraction. GeroScience, vol 46 (1).
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Written by: Milda Milčiūtė
Cover image credits: tippapatt/ Adobe Stock
